Aminobenzoic acids and derivatives
Aobchem 4-Chloro-N-methylbenzamide | 95% | CAS 6873-44-5 | C8H8ClNO | 1g
4-Chloro-N-methylbenzamide | 95% | CAS 6873-44-5 | C8H8ClNO | 1g
Aobchem 4-Chloro-N-methylbenzamide | 95% | CAS 6873-44-5 | C8H8ClNO | 500mg
4-Chloro-N-methylbenzamide | 95% | CAS 6873-44-5 | C8H8ClNO | 500mg
Aobchem 2-Bromo-5-methylbenzamide | ≥97% | CAS 101421-61-8 | C8H8BrNO | 250mg
2-Bromo-5-methylbenzamide | ≥97% | CAS 101421-61-8 | C8H8BrNO | 250mg
Aobchem N-cyclopentyl-3-methylbenzamide | 95% | CAS 349403-64-1 | C13H17NO | 1g
N-cyclopentyl-3-methylbenzamide | 95% | CAS 349403-64-1 | C13H17NO | 1g
Medchemexpress LLC KB-R7943 mesylate | 182004-65-5 | C17H21N3O6S2 | 5 MG
KB-R7943 mesylate is an inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with an IC50 of 5.7±2.1 μM. It induces cancer cell death by activating the JNK pathway and blocking autophagic flux. It also blocks NMDAR-mediated ion currents, inhibits NMDA-induced increases in cytosolic Ca2+ (IC50 of 13.4±3.6 μM), and accelerates calcium deregulation in glutamate-treated neurons. Additionally, it depolarizes mitochondria in a Ca2+-independent manner and inhibits 2,4-dinitrophenol-stimulated respiration (IC50 of 11.4±2.4 μM) in cultured neurons.
- Inhibits reverse Na+/Ca2+ exchanger (NCXrev)
- Induces cancer cell death by activating JNK pathway
- Blocks autophagic flux
- Blocks NMDAR-mediated ion currents
- Inhibits NMDA-induced increases in cytosolic Ca2+
- Accelerates calcium deregulation and mitochondrial depolarization in glutamate-treated neurons
- Depolarizes mitochondria in a Ca2+-independent manner
Medchemexpress LLC CEP-28122 (mesylate salt) | 2070009-30-0 | 99.9% | 635.17 | 100 MG
CEP-28122 (mesylate salt) | 2070009-30-0 | 99.9% | 635.17 | 100 MG
Medchemexpress LLC Cep-28122 (mesylate salt) | 2070009-30-0 | 99.9% | 635.17 | 1 ML
CEP-28122 mesylate salt, a diaminopyrimidine derivative, is a potent, selective, and orally active ALK inhibitor with an IC50 value of 1.9 nM. It exhibits antitumor activity in experimental models of ALK-positive human cancers and possesses good pharmacodynamic and pharmacokinetic activity. This product can be utilized for the study of ALK-positive anaplastic large-cell lymphoma (ALCL), non-small cell lung cancer (NSCLC), and neuroblastoma cells.
- Potent, selective, and orally active ALK inhibitor with an IC50 value of 1.9 nM.
- Exhibits antitumor activity in experimental models of ALK-positive human cancers.
- Possesses good pharmacodynamic and pharmacokinetic activity.
- Can be used for the study of ALK-positive anaplastic large-cell lymphoma (ALCL), non-small cell lung cancer (NSCLC), and neuroblastoma cells.
Medchemexpress LLC Pritelivir mesylate | 1428333-96-3 | C19H22N4O6S3 | 100 MG
Pritelivir mesylate is an inhibitor of the viral helicase-primase complex. It demonstrates antiviral activity both in vitro and in animal models of herpes simplex virus (HSV) infection, effective against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2).
- Inhibits viral helicase-primase complex
- Exhibits antiviral activity against HSV-1 and HSV-2
- IC50 of 0.02 μM against HSV1-2
- For research use only
- Purity of 99.33%
- Appearance is solid
- Color is white to off-white
Medchemexpress LLC SNS-314 mesylate | 1146618-41-8 | 99.5% | 1 ML
SNS-314 mesylate is a potent, selective small-molecule inhibitor of Aurora kinases A, B, and C, with reported IC50 values of approximately 9 nM, 31 nM, and 6 nM, respectively. It is supplied for research use in solid form and as a ready-to-use 10 mM solution in DMSO.
- Potent inhibition of Aurora A, B, and C (IC50: ~9, 31, and 6 nM)
- High reported purity suitable for biochemical assays
- Available as solid and as 10 mM solution in DMSO for convenience
- Stable when stored sealed at recommended temperatures
- White to light yellow solid, easy to handle
Apexbio Technology LLC Dabrafenib Mesylate (GSK-2118436) 1195768-06-9 10mg
Dabrafenib Mesylate (GSK-2118436 CAS 1195768-06-9) is a potent orally active inhibitor that specifically targets the mutant BRAF kinase variant V600E BRAF functions as a serine/threonine kinase essential in the MAPK/ERK signaling cascade frequently mutated in various human cancers Dabrafenib selectively inhibits BRAF V600E (IC50 0 8 nM) with lower activity against wild-type B-Raf and c-Raf By binding and disrupting BRAF V600E activity dabrafenib attenuates downstream MAPK/ERK activation leading to reduced cellular proliferation and tumorigenicity This agent is useful for investigating oncogenic pathways and was FDA-approved for metastatic melanoma with BRAF V600E mutation
Medchemexpress LLC Obatoclax mesylate | 803712-79-0 | 99.9% | 413.49 | 1 ML
Obatoclax Mesylate is a BH3 mimetic and a pan-BCL-2 family proteins inhibitor that induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. It exhibits anti-cancer and broad-spectrum antiparasitic activity.
- Inhibits BCL-2 family proteins including BCL-2, BCL-XL, MCL-1, BCL-w, A1, and BCL-b
- Induces autophagy-dependent cell death
- Targets cyclin D1 for proteasomal degradation
- Demonstrates anti-cancer and broad-spectrum antiparasitic activity
- Reduces cell numbers in human colorectal cancer cell lines (HCT116, HT-29, LoVo)
- Increases G1-phase cell populations
- Causes a marked drop in cyclin D1 levels, inhibits GSK3β, and activates p38MAPK
- Shows potent antitumor activity in xenograft mouse models
Aobchem Methyl 5-bromo-6-methylbenzo[b]thiophene-2-carboxylate | 97% | CAS 2166801-66-5 | C11H9BrO2S | 1g
Methyl 5-bromo-6-methylbenzo[b]thiophene-2-carboxylate | 97% | CAS 2166801-66-5 | C11H9BrO2S | 1g
Aobchem 2-(Ethylthio)-5-methylbenzo[b]thiophene | 97% | CAS 3002471-08-8 | C11H12S2 | 1g
2-(Ethylthio)-5-methylbenzo[b]thiophene | 97% | CAS 3002471-08-8 | C11H12S2 | 1g
Aobchem 3-Methoxy-2 5-dimethylbenzoic acid | ≥97% | CAS 92315-49-6 | C10H12O3 | 500mg
3-Methoxy-2 5-dimethylbenzoic acid | ≥97% | CAS 92315-49-6 | C10H12O3 | 500mg
![Aobchem 4-Methylbenzo[b]thiophene-2-carboxylic acid | ≥97% | CAS 1735-13-3 | C10H8O2S | 5g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000984568.png-250.jpg)
Aobchem 4-Methylbenzo[b]thiophene-2-carboxylic acid | ≥97% | CAS 1735-13-3 | C10H8O2S | 5g
4-Methylbenzo[b]thiophene-2-carboxylic acid | ≥97% | CAS 1735-13-3 | C10H8O2S | 5g